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Kinase inhibitor
Kinase inhibitor
Signal Transduction during Legionella pneumophila Entry into Human Monocytes
Cytoskeleton / Signal Transduction / Biological Sciences / Infection and immunity / Humans / Legionella pneumophila / Escherichia coli / Infection / Kinase inhibitor / Phosphorylation / Phagocytosis / Monocytes / Alveolar Macrophage / Tyrosine Kinase / Tyrosine Phosphorylation / Legionella pneumophila / Escherichia coli / Infection / Kinase inhibitor / Phosphorylation / Phagocytosis / Monocytes / Alveolar Macrophage / Tyrosine Kinase / Tyrosine Phosphorylation
Optimal Experimental Design For Parameter Estimation In Biological Signal Transduction Modeling
Environmental Engineering / Civil Engineering / Algorithms / Analytical Chemistry / Research Design / Signal Processing / Food Engineering / Water resources / Kinetics / Systems Biology / Fluorescence Microscopy / Heat Transfer / Finite element method / Cell Signaling / Confocal Microscopy / Finite Element / Applied Economics / Numerical Method / Parameter estimation / Biological Sciences / Optimal Control theory / Mathematical Sciences / Mice / Animals / Iterative Design / Kinase inhibitor / Solute transport / PARTIAL DIFFERENTIAL EQUATION / Inverse Problem / Thermal Conductivity / Heat Conduction / Heat Capacity / Information Content / Inverse Modeling / Thermophysical Properties / Simulation Study / Food Sciences / Differential equation / Optimal Design / Cell communication / Boundary Condition / Water Flow / Experimental Data / Kinetic Parameter / Second Messengers / Mean-variance / Ordinary Differential Equation / Unsaturated Zone / Parameter Uncertainty / Signal Processing / Food Engineering / Water resources / Kinetics / Systems Biology / Fluorescence Microscopy / Heat Transfer / Finite element method / Cell Signaling / Confocal Microscopy / Finite Element / Applied Economics / Numerical Method / Parameter estimation / Biological Sciences / Optimal Control theory / Mathematical Sciences / Mice / Animals / Iterative Design / Kinase inhibitor / Solute transport / PARTIAL DIFFERENTIAL EQUATION / Inverse Problem / Thermal Conductivity / Heat Conduction / Heat Capacity / Information Content / Inverse Modeling / Thermophysical Properties / Simulation Study / Food Sciences / Differential equation / Optimal Design / Cell communication / Boundary Condition / Water Flow / Experimental Data / Kinetic Parameter / Second Messengers / Mean-variance / Ordinary Differential Equation / Unsaturated Zone / Parameter Uncertainty
Expression of Nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues
Cell line / Humans / Female / Male / Kinase inhibitor / Aged / Middle Aged / mRna expression levels / Oral Squamous Cell Carcinoma (OSCC) / Epidermal Growth Factor / Epidermal Growth Factor Receptor / In Vitro Studies / Growth Factor / Detection Rate / Gtp Binding Proteins / Aged / Middle Aged / mRna expression levels / Oral Squamous Cell Carcinoma (OSCC) / Epidermal Growth Factor / Epidermal Growth Factor Receptor / In Vitro Studies / Growth Factor / Detection Rate / Gtp Binding Proteins
Src Kinase Inhibition Improves Acute Outcomes After Experimental Intracerebral Hemorrhage
Behavior / Treatment Outcome / Enzyme Inhibitors / Apoptosis / Stroke / Glucose Metabolism / Animals / Male / Cell Death / Kinase inhibitor / Clinical Sciences / Apoptose / Src kinase / Rats / Blood Flow / Intracerebral Hemorrhage / Pyrazoles / Cerebral Hemorrhage / Neurosciences / Direct Injection / Matrix Metalloproteinase / Glucose Metabolism / Animals / Male / Cell Death / Kinase inhibitor / Clinical Sciences / Apoptose / Src kinase / Rats / Blood Flow / Intracerebral Hemorrhage / Pyrazoles / Cerebral Hemorrhage / Neurosciences / Direct Injection / Matrix Metalloproteinase
Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice
Magnetic Resonance Imaging / Immunohistochemistry / Brain Tumor / Humans / Mice / Glioblastoma / Animals / Clinical / Clinical oncology / Kinase inhibitor / Antineoplastic Agents / Protein Kinase Inhibitors / Brain Edema / Brain Neoplasms / Vascular endothelial growth factor receptor / Quinazolines / Glioblastoma / Animals / Clinical / Clinical oncology / Kinase inhibitor / Antineoplastic Agents / Protein Kinase Inhibitors / Brain Edema / Brain Neoplasms / Vascular endothelial growth factor receptor / Quinazolines
Antitumor effect of gefitinib (‘Iressa’) on esophageal squamous cell carcinoma cell lines in vitro and in vivo
Flow Cytometry / Cell Cycle / Signal Transduction / Cell line / Humans / Cancer Therapy / Mice / Female / Animals / Kinase inhibitor / Oral Squamous Cell Carcinoma (OSCC) / Epidermal Growth Factor Receptor / Tyrosine Kinase Inhibitor / factor VIII / Growth Inhibition / Cell Proliferation / Cell Cycle Arrest / Antitumor Activity / Growth Factor / Antineoplastic Agents / Cell Sorting / Nude mice / Growth factor receptor / Quinazolines / Cancer Therapy / Mice / Female / Animals / Kinase inhibitor / Oral Squamous Cell Carcinoma (OSCC) / Epidermal Growth Factor Receptor / Tyrosine Kinase Inhibitor / factor VIII / Growth Inhibition / Cell Proliferation / Cell Cycle Arrest / Antitumor Activity / Growth Factor / Antineoplastic Agents / Cell Sorting / Nude mice / Growth factor receptor / Quinazolines
Strongyloides stercoralis age-1: A Potential Regulator of Infective Larval Development in a Parasitic Nematode
Caenorhabditis elegans / Computational Biology / Molecular Genetics / Multidisciplinary / Quantitative PCR / Phylogeny / Animals / Transgenic Animals / Cluster Analysis / Kinase inhibitor / Phylogenetic analysis / Life Cycle / PLoS one / Molecular cloning / Strongyloides Stercoralis / Larva / Amino Acid Profile / Amino Acid Sequence / Base Sequence / Larval Development / Confidence Interval / Phylogeny / Animals / Transgenic Animals / Cluster Analysis / Kinase inhibitor / Phylogenetic analysis / Life Cycle / PLoS one / Molecular cloning / Strongyloides Stercoralis / Larva / Amino Acid Profile / Amino Acid Sequence / Base Sequence / Larval Development / Confidence Interval
Comparison of human COP9 signalosome and 26S proteasome ‘lid’
Signal Transduction / Humans / Protein Kinases / Mice / Animals / Kinase inhibitor / Red blood cell / Molecular Mass / MAP Kinase / Biochemistry and cell biology / Molecular Biology Reports / Kinase inhibitor / Red blood cell / Molecular Mass / MAP Kinase / Biochemistry and cell biology / Molecular Biology Reports
Viral and cellular kinases are potential antiviral targets and have a central role in varicella zoster virus pathogenesis
Cell Cycle / Enzyme Inhibitors / Biological Sciences / Cell line / Humans / Cytomegalovirus / Physical sciences / Kinase inhibitor / Cdk / Antiviral Activity / Antiviral Agents / Varicella Zoster Virus / Cytomegalovirus / Physical sciences / Kinase inhibitor / Cdk / Antiviral Activity / Antiviral Agents / Varicella Zoster Virus
Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors
Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Humans / Kinase inhibitor / Hydrogen Bond / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Alkynes / Molecular Structure / Receptor Tyrosine Kinase / Hydrogen Bond / Bioorganic and medicinal Chemistry / Cell Proliferation / Structure activity Relationship / Alkynes / Molecular Structure / Receptor Tyrosine Kinase
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity
Organic Chemistry / Mice / Animals / Drug Design / Kinase inhibitor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor
Stretch Activates Nitric Oxide Production in Pulmonary Vascular Endothelial Cells In Situ
Fluorescence Microscopy / Immunohistochemistry / Protein synthesis / Signal Transduction / Free Radical / Endothelial Cells / Mice / Blood Pressure / Nitric oxide / Animals / Kinase inhibitor / American / Shear Stress / Enzyme / Rats / Nitric Oxide Synthase / Endothelial cell / Shear Strength / Shear Force / Vascular Endothelial Function / Pressure Gradient / Cell Cell Interaction / Pulmonary circulation / Endothelial Cells / Mice / Blood Pressure / Nitric oxide / Animals / Kinase inhibitor / American / Shear Stress / Enzyme / Rats / Nitric Oxide Synthase / Endothelial cell / Shear Strength / Shear Force / Vascular Endothelial Function / Pressure Gradient / Cell Cell Interaction / Pulmonary circulation
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity
Organic Chemistry / Cancer / Mice / Animals / Drug Design / Kinase inhibitor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor / Aurora B / Kinase inhibitor / Bioorganic and medicinal Chemistry / Biological activity / Aurora kinases / Structure activity Relationship / Molecular Structure / Vascular endothelial growth factor receptor / Aurora B
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